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46 These molecular responses favored nilotinib over imatinib based on historical controls.
The authors considered all neoplastic lesions observed in the kidneys, spleen, and testes to be spontaneous for the male F344 rat and male B6C3F1 mouse based on historical controls, but data were not shown.
During this uncontrolled extension phase, there were 14 deaths with a calculated survival rate of 97%, substantially greater than the expected survival rate of 71% based on historical controls (Sastry 2006).
However, the spontaneous mutant frequency was higher than expected based on historical controls (example: [ 28]), mostly due to animal Control20, which had a mutant frequency of 17.8 × 10−5.
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This approach is relatively conservative, as it keeps separate the variability of estimates of the treatment effect in the historical studies and the variability observed in the NI trial, and uses a fixed value for the estimate of the control effect based on historical data (the 90% or 95% CI lower bound), a relatively conservative estimate of the control drug effect.
The survival curves in an existing control group based on historical data and the PRP-treated group until wound closure will be evaluated according to the Kaplan-Meier method, and a stratified analysis will be performed using the log-rank test.
One of the key requirements for dynamic resource allocation framework is to predict traffic in the next control time interval based on historical data and online measurements of traffic characteristics over appropriate timescales.
Incoming material control 222 2 Incoming material control was done by visual inspections based on historical experience in all farms.
The expected control incidence was calculated based on historical incidences weighted to account for patients with previous rituximab treatment.
Based on historical data, this system is designed to forecast water quality with artificial neural networks (ANNs) and control the water quality in time to reduce catastrophic losses.
Facebook is also introducing new tools and controls for groups, including a Group Insights tool that offers tips like when to schedule posts based on historical member engagement data.
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