Sentence examples for based on histone modifications from inspiring English sources
In fact, according to Lewis et al., an ancestral imprinting mechanism, restricted to the placenta, is based on histone modifications [ 135 ], which may confer the short-term and flexible response implicated in development [ 136 – 138 ].
This is in agreement with a previous report in which the majority of genome-wide orphan CpG islands were predicted to be associated with the promoters of unknown genes based on histone modifications and the presence of RNA Pol II (Illingworth et al. 2010).
While features based on histone modifications contain enough information to obtain good and reproducible classifier training, we wanted to verify if the same can be predicted from the DNA sequence of the respective sequences and to what extent the sequence motif information is redundant with the epigenetic component.
Thus, Bayesian Neural Networks was used to classify functional and non-functional binding sites [ 8] based on histone modification levels at the ORFs.
Interestingly, clustering of TFs based on histone modification variation scores defined a group of TFs where known or potential hematopoietic-specific TFs were remarkably enriched.
In order to make prediction of HPTFs based on histone modification dynamics, we made binary partition of all TFs' histone modification variation scores (i.e., combining histone modification variation scores "0" and "1 " into "Low_V," "2" and "3" into "High_V").
In this report, we provide a proteomic atlas of cancer lines based on histone modification patterns, and a companion genomic atlas of the same lines based on expression of histone modifying enzymes.
For classification based on histone modification features, we utilize an ensemble method, random forests [ 24], which has been widely demonstrated to improve on individual classification trees [ 24, 25], as were deployed by Gervais and Gaudreau [ 13].
