Sentence examples for based on histone modification from inspiring English sources

ChromaSig developed by Hon et al. is one algorithm that can find recurring chromatin signatures based on histone modification profiles [62].

Epigenetic regulation based on histone modification is essential for numerous biological processes in eukaryotic organisms1,2.

Clustering of P. falciparum CVM genes based on histone modification profiles.

Gene Ontology (GO) Analysis of the clusters based on histone modification profiles.

Interestingly, clustering of TFs based on histone modification variation scores defined a group of TFs where known or potential hematopoietic-specific TFs were remarkably enriched.

Thus, Bayesian Neural Networks was used to classify functional and non-functional binding sites [ 8] based on histone modification levels at the ORFs.

In fact, according to Lewis et al., an ancestral imprinting mechanism, restricted to the placenta, is based on histone modifications [ 135 ], which may confer the short-term and flexible response implicated in development [ 136 – 138 ].

This is in agreement with a previous report in which the majority of genome-wide orphan CpG islands were predicted to be associated with the promoters of unknown genes based on histone modifications and the presence of RNA Pol II (Illingworth et al. 2010).

While features based on histone modifications contain enough information to obtain good and reproducible classifier training, we wanted to verify if the same can be predicted from the DNA sequence of the respective sequences and to what extent the sequence motif information is redundant with the epigenetic component.

To better understand the functional difference of the enhancer classes defined based on their histone modification states, we asked if there is a correlation between enhancer histone modification state and expression level of their target genes.

We assigned labels to each cluster based on the histone modification pattern and genomic localization.