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Further stratified analyses based on histological grade and tumor size were performed.
Comparison of groups distinguished based on histological grade, FIGO stage and myometrial invasion did not revealed any significant differences.
In the present work, we were unable to stratify the groups based on histological grade or the smallest region of overlap involved in LOH, since larger cohorts of patients are needed for this analysis.
'Luminal A' tumours are ER+ and/or PR+, HER2− and have <14% of the nuclei staining positive for Ki-67 (or, when based on histological grade, grade 1 or 2).
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Therefore, we could not include a large number of patients and also did not try to stratify the lot based on histological grading.
Comparison between groups distinguished based on histological grading revealed the lowest miR-99a expression in G3 samples, which was significantly different from G2 samples (p = 0.047) and combined G1 and G2 samples (p = 0.029).
Two of these (Albertsen et al, 1998; Johansson et al, 2004) estimated outcome based on histological tumour grade, but did not include either clinical stage or initial serum PSA level and reviewed Gleason grades.
The features were created based on histological basis (two histologic grades times three histological types).
Breast tumours are currently primarily classified based on histological appearance or grade, as well as using certain molecular biomarkers.
Since treatment decisions are based on histological diagnosis and grading, this affects patient care: erroneous classification and grading may result in both over- and undertreatment.
Cancers were assigned a prognostic risk group [ 9], based on histological type and malignancy grade [ 15- 17].
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