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The further analysis was done based on highest sequence identity and smallest distance from PK-NCVI/Pk3a as potential templates with comparative modeling, including PDB Ids 3KQN [ 19] (X-ray structure of hepatitis C virus NS3 helicase in complex with ssRNA), 3O8B [ 14] (Crystal structure of HCV NS3 protein), and 1CU1 [ 15].
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In this work, we have proposed a stringent DDI-based prediction approach based on high sequence similarity between template domain instances and query domain instances.
The TaGPX genes were scattered on the various chromosomes of the A, B, and D sub-genomes and clustered into five homeologous groups based on high sequence homology.
Briefly, both HCNRs were selected based on high sequence conservation with human genome by using VISTA browser (http://pipeline.lbl.gov/cgi-bin/gateway2).
It was predicted that insertions in PEST suspected to be relatively ancient based on high sequence divergence from the family consensus would be fixed within and among natural populations.
The identified AGO genes are named SmAGO1 to SmAGO10, respectively, based on high sequence similarity with corresponding Arabidopsis AGOs.
Although LNX5 (PDZRN4LPDZRN4lackscks the RING domain, it is clearly a member of the family based on high sequence homology to LNX3 and LNX4 [ 3, 4].
Moreover, several studies show that they still might be active today based on high sequence conservation, nearly identical LTRs, and the presence of TSD (Witte et al. 2001; Zhou and Cahan 2012).
Based on high sequence similarity with homologs in other xanthomonads, genes of this pathway seem to be functional in the genome of Xff 4834-R, withethexceptionof of hmgA, the gene encoding the homogentisate oxygenase.
KEGG reactions were considered as present in P. falciparum, if genes were assigned via the KEGG Orthology (KO), a classification of orthologous and paralogous groups of genes based on high sequence similarities to genes of known function.
Our genome-wide analysis detected four HKs in soybean that can be classified as ERS1 and ETR1 ethylene receptor HK orthologues based on high sequence identity with their Arabidopsis counterparts (Fig. 1).
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