Sentence examples for based on highest risk from inspiring English sources

Because any given protocol may contain many procedures and hence, a range of risk levels, the selection of the essential safeguards to protect vulnerable subjects should be based on highest risk level present in the protocol.

As a result, DM will not select strategies based on high risk segments, and the company could lead its investment to the most secure space.

Of the 2,546 individuals enrolled in the trial based on high risk for infection through injection drug use (IDU), we obtained clinical samples and HIV-1 sequence data (envelope glycoprotein gene gp120) from 215 individuals who became infected during the trial.

Since the 1990s, nationwide clinical guidelines based on high risk approach have been implemented to improve maternal and perinatal health [ 36].

Our study was based on high risk pregnancies those clinically indicated for amniocentesis or chorionic villus sampling which ensured that full karyotyping results were available from each pregnancy.

This was based on high risk as a result of inadequate random sequence generation, since treatment was randomly allocated to groups of children determined by the investigators; unclear risk due to inadequate allocation concealment; and high risk from differential attrition between treatment arms.

In the Australian cohort, indications to conduct this procedure were primarily to exclude aneuploidy based on high risk findings at either first trimester screening (ultrasound measurement of fetal nuchal translucency and maternal biochemistry) or second trimester maternal serum screening (maternal biochemistry) with no apparent fetal structural anomalies.

In the present study, polymorphisms have been selected from genes in the renin-angiotensin and fibrinolytic pathways to assess the genetic contribution to the protein concentrations of t-PA and PAI-1 in a large-scale population-based cohort; this study supplements the available literature that is primarily based on high-risk populations.

Systemic safety improvement means a proven safety countermeasure(s) that is widely implemented based on high-risk roadway features that are correlated with particular severe crash types.

CONTEXT: Previous studies of BRCA1 mutation prevalence have been based on high-risk groups, yielding estimates that do not reflect the experience of the general population of US patients with breast cancer.

The modifying effect may explain the previously reported differences between population based estimates for BRCA1/2 penetrance and estimates based on high-risk families.