Topic experts consulted, for example, regarding orthopaedic management or management of sleep disturbance, confirmed equipoise based on high-quality research evidence, even if their personal views were less uncertain.
We agree with the recently expressed view that unless recommendations are based on high quality primary research, then perhaps guidelines should be avoided completely, and clinicians would be better off making clinical decisions on the basis of primary data' [ 4].
The authors initially forward the view that 'unless recommendations are based on high quality primary research... clinicians would be better off making clinical decisions on the basis of primary data' - just to end doing the opposite by recommending against the use of balanced colloid solutions based on 'limited published information' [ 1].
Overall, our results are based on "high quality" evidence (GRADE), and therefore further research is unlikely to change this evidence.
However, it seems to have bright prospects because it is based on high quality and well subsidized fundamental and applied research in cell biology, molecular biology, biology of aging, and related fields.
GHA welcomes papers presenting solid scientific evidence on population health, based on high quality epidemiological studies, especially in low- and middle-income countries and utilising longitudinal infrastructures for population research.
However, we would also argue that the use of research findings in this case had symbolic value, indicating to the potential users of the policies and to other actors that South Africa was part of the broader international movement to base clinical policies and practice on high quality research evidence.
Good care for older people should be based on high-quality, ethically sound, relevant research involving this patient population. 1 This must include studies in nursing and residential homes, where many of the growing numbers of frail older people live.
In an ideal world, all knowledge used in industry, education and research should be based on high-quality evidence.
This study was based on high-quality cancer registration data.
