Because we wished to explore the prevalence and significance of anemia of varying degrees of severity, we classified anemia based on hemoglobin values into categories consisting of no anemia (>13 g/dL), at least borderline (≤ 13 g/dL), at least mild (≤ 12 g/dL), at least moderate (≤ 10 g/dL), and severe (≤ 8 g/dL) anemia.
In order to further refine this analysis according to a primary indication for RBC transfusion (hemoglobin nadir less than 10 grams per deciliter (g/dL)) or inotrope administration (hemoglobin nadir of 10 g/dL or greater) for treatment of ScvO2 values <70%, we divided the cohort based on hemoglobin nadir values during the first six hours of EGDT eligibility.
The current diagnostic criteria for PV are based on hemoglobin level and presence of the JAK2 V617 mutation.
Retinal oximetry measures vascular oxygen tension in inner retinal and choroidal vasculature based on hemoglobin oxygen saturation.
All of the participating thalassemia trait pregnant women were diagnosed based on hemoglobin typing and/or DNA analysis.
Serum Hp concentration was estimated based on hemoglobin-binding capacity in microtitration plates, as previously described [ 11].
Approximately 8.9 million people are estimated to have diabetes based on a hemoglobin A1c (HbA1c) value of 6.1% or more or being recipients of treatment for T2D.
To further examine the relationship between baseline hemoglobin, serum ferritin, and changes in posttreatment hemoglobin levels, C282Y-homozygous patients in each of the two SF categories were divided into those with hemoglobin <150 and ≥150 g/L or <138 and ≥138 g/L based on mean baseline hemoglobin values for male and female patients, respectively.
Analysis of monthly hemoglobin was based on the value closest to the date of the scheduled time point (eg, month 1, 2, 3) within a ± 2-week window, with the exception of the Q2W conversion time point which included values up to 8 weeks before conversion to ensure the maximum number of patients for evaluation.
