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Patients were divided based on glomerular filtration rate (GFR).
Kidney function was determined based on glomerular filtration rate (GFR), urine volume, urine osmotic pressure (Osmomat 030-D; Gonotec GmbH, Berlin, Germany), N-acetyl-β-d-glucosaminidase (NAG) levels (Shionogi & Co., Osaka, Japan), and urine pH (Pretest 5bII; Wako Pure Chemical Industries, Tokyo, Japan).
Patients had been previously diagnosed with CRD based on glomerular filtration rates estimated from serial serum creatinine values.
CKD is currently classified into five stages based on glomerular filtration rate (GFR) as recommended by many professional guidelines (Table 1) [ 2].
Patients with maximum RIFLE class F based on glomerular filtration rate criteria had a somewhat higher inhospital mortality compared with patients who had a maximum RIFLE class F on urine output criteria (27.9% versus 21.9%, P = 0.020).
AKI was defined according to the pediatric RIFLE (pRIFLE) score (acronym of Risk for renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function, and End-stage renal disease), recently proposed for AKI diagnosis and classification in children based on glomerular filtration rate and UO criteria [ 13].
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Though widely used for both epidemiological and clinical purposes, this 5-stage system has been criticized for being based primarily on glomerular filtration rate (GFR), as calculated by the use of equations which may not provide accurate estimates, especially in elderly and female individuals [ 2].
Objective To determine the cost effectiveness of one-off population based screening for chronic kidney disease based on estimated glomerular filtration rate.
Currently, CKD is staged based on estimated glomerular filtration rate (eGFR), derived from serum creatinine values in one of several formulas [ 2].
The aim of the study was to determine whether a vancomycin dosing algorithm based on estimated glomerular filtration rate from creatinine and cystatin C levels (eGFRcr-cys) improves target trough concentration achievement compared to an algorithm based on estimated creatinine clearance (eCLcr) in critically ill patients.
We conducted a population-based cross-sectional study in Golestan and collected a wide range of data to evaluate renal function, based on estimated glomerular filtration rate (GFR), in the general population and to investigate risk factors of moderate to severe CKD in the region.
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