Exact(1)
Examples are shown based on globin sequences from various species and on the abnormal human hemoglobins.
Similar(59)
Molecular phylogenetic reconstructions based on globin amino acid sequence data have shown that Drosophila glob1 forms a clade with the globins of chironomids and the horse botfly G. intestinalis [ 18].
Although earlier alignments [ 74] had suggested that globins were characterized by two invariant residues, F8His and CD1Phe, more recent information on globin sequences [ 1, 2] indicate that other hydrophobic residues, such as Tyr/Met/Leu/Ile/Val can occur at the CD1 position as well as Ala/Ser/Thr/Leu at the distal E7 position, in addition to His and Gln.
A subsequent study by Moens et al. [ 96] based on 700 sequences, including bacterial ones, proposed that all globins «evolved from a family of ancestral, ca. 17 kDa hemeproteins, which displayed the globin fold and functioned as redox proteins».
Phylogenies based on noncoding sequences indicate that the α-globin genes found in the dolphin and in the killer whale are 1 1 orthologs to the α-globin gene repertoire present in other mammals (fig. 2).
Phylogenies based on noncoding sequences indicate that the β-globin genes found in both the dolphin and the killer whale are 1 1 orthologs to the β-globin gene repertoire in other mammals (fig. 3).
The first attempt at defining the molecular phylogeny of globins [ 95] was a tree based on 245 sequences, all from eukaryotes.
To this end, we performed an unbiased characterization of the genetic diversity at the β-globin cluster based on Sanger sequencing of both HBB and HBD in ethnically diverse samples from Europe and Africa and on the sequence data from the 1000 Genomes Project Consortium (Altshuler et al. 2012).
Bisulfite-sequencing was based on nucleotide sequences in electropherograms.
based on these sequences.
These analyses were based on nucleotide sequences.
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