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The significance results presented should be based on genotype distributions using both the 1 degree of freedom trend test and 2 degree of freedom tests, rather than allelic tests.
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No individual SNP has, to date, given a P value for association (based on genotype distribution) lower than 10-4.
Our data demonstrated 100% concordance between the two different specimens, except a discrepancy in one sample for the miR-146a SNP (Table 1, Additional file 1: Table S5).> After adjustment for confounding factors (sex and age), the results of the risk estimation analysis based on genotype distribution, allele frequency, and genetic model by logistic regression analysis are shown in Table 2.
Based on the genotype distributions in meta-analyses, allele frequencies and the case-control differences were calculated.
Based on the genotype distributions in the meta-analyses, allele frequencies and the case control differences were calculated.
Based on the genotype distributions of the strongly linked rs12979860 SNP, we could assume that almost 40% of Caucasians express IFNL4.
Animals were used based on genotypes.
Fisher's exact tests were also performed on genotype distributions.
As the true genotype distribution diverged from HWE, classification based on the true genotype distribution had smaller genotype-call error than classification based on HWE.
It is not immediately obvious how one would apply methods based on comparing distributions of genotypes in mixed-sex studies, since male and female genotypes are qualitatively different.
In contrast, a recessive model was used for the XPD Lys751Gln polymorphism based on the observed genotype distributions and some earlier publications [ 42, 51].
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