Although this is typically regarded as a black box approach (e.g., [ 40]), dissection of available SNPs based on genomic annotation may be an attractive strategy for understanding which genomic segments drive higher predictive performance of yet-to-be observed phenotypes.
A computational model that can accurately predict splicing patterns based on genomic features and cellular context is highly desirable, both in understanding this widespread phenomenon, and in exploring the effects of genetic variations on AS.
These findings helped in understanding the intraspecies (strains) diversity and/or similarity and its correlation with that of phylogenomic variations based on genomic contents.
Hu, G. & Agarwal, P. Human disease drug network based on genomic expression profiles.
Notta, F. et al. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.
Duarte, N. C. et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data.
Enault, F., Suhre, K. & Claverie, J.M. Phydbac "Gene Function Predictor": a gene annotation tool based on genomic context analysis.
Ramos, M.L. et al. Chromosomal and phylogenetic context for conglutin genes in Arachis based on genomic sequence.
There has recently been a significant move towards offering more personalised medical treatments based on genomic research.
Such stratification, based on genomic drivers, will be important for selecting patients for clinical trials.
