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Clinical laboratories are naturally striving to implement molecular diagnostic tests based on genomic methods such as massively parallel sequencing in order to provide genetic diagnosis at the genome scale, while leveraging the parallel processing and nanoscale architecture inherent in these technologies to consolidate costs and maintain turnaround times.
This analysis, based on genomic methods, yielded new information that can be used for generating a mechanistic hypothesis for further study of perinatal exposure of PDBE using traditional methods of toxicology.
Similar(58)
In recent years, many bioinformatics methods have been adapted to PPI calculations and have been categorized into four types of methods: methods based on genomic information; methods based on evolutionary relationships; methods based on protein sequences (ab initio); and methods based on protein 3-dimensional structural information.
Our results indicate a strikingly higher sensitivity of the extended Taxy-Pro mixture model when compared with homology-based classification methods merely based on genomic reference data.
However, even these methods generate false positives, and, we used additional methods based on genomic information to add confidence to our assignment of sequences to the helical cytokine family.
So far, studies aimed at elucidating integration specificity were largely based on genomic screening and molecular biology methods.
Methods based on genomic approaches and amongst them global gene expression profiles play an increasing role in such efforts.
Methods based on genomic comparison, detection of composition bias and search of mobility genes are the most performing tools for the flexible genome characterization [ 45].
This approach of analysing metabolism as a single network allows a global view of functional processes, which was enabled by metabolic reconstruction methods based on genomic data [ 33- 37].
Data normalization and analysis was carried out using the program ArrayLeaRNA, which implements a Bayesian inference method based on genomic controls and operon transcription pattern [ 63].
For example, Ranz et al. [ 18] introduced a probe selection method based on genomic DNA hybridizations of the target and non-target species to the GeneChip.
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