Thus, this is a powerful approach that may be useful to identify therapies that target a cancer phenotype that can be distinguished based on genomic expression.
We delineate selection criteria for CRC derived cell lines based on genomic expression patterns related to clinical parameters, migratory capacities and proliferative activities.
In addition, patients may group into "treatment clusters," which may lead to novel clinical trial designs that classify patients to a particular treatment plan based on genomic expression differences.
Confirmation of the expression of merE (E2, E3, E4, E5, E6, and E7) in transgenic plants based on genomic PCR expression analysis (B).
Based on genomic, cDNA, expression and phylogenetic data, we report a novel lineage of immunoglobulin receptors belonging to the KIR family, which is highly conserved throughout 50 million years of primate evolution.
To simplify this list for further study in an in vivo model system, we developed a strategy based on genomic resources, expression analysis and available functional data: we first identified the 43 genes with zebrafish orthologs, some of which have a and b isoforms (Fig. 1).
Based on genomic location and expression analysis, we also identified those miRNAs that are likely to be encoded as part of polycistronic transcripts.
This interpretation is similar to the approach of Domcke et al. [ 45] of choosing the 'most suitable models' for ovarian tumour among ovarian cancer cell lines based on genomic and mRNA expression profiles.
To examine the divergence between cultivated and wild rice at genetic, methylation and gene expression levels, we first constructed trees based on genomic, methylomic, and gene expression data, respectively (see Materials and methods).
After profiling a cohort of tumors, such as in the TCGA project, the common follow-up analysis is to cluster the tumors into subgroups based on genomic features, such as gene expression.
Moreover, none of the signals differentiating the two sexes by MALDI profiling corresponded to the theoretical molecular weight of proteins encoded by genes showing differential expression levels based on genomic analyses [4], [6].
