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The topology of the resulting guide tree may not represent the clonal genealogy of the organisms, however, we have found that guide trees based on genomic content allow our algorithm to produce better alignments.
The analysis we here report is based on genomic content of protein domain structures at FSF level of the structural hierarchy.
We used hierarchical clustering based on the M-CGH results to examine the relationship between A. pleuropneumoniae serovars based on genomic content.
Clustering based on genomic content showed that B. pertussis strains isolated in different countries are mostly similar and did not reveal a particular geographic region of a specific strain.
If gain and loss happened randomly and at constant rates, the tree based on genomic content would be expected to to be very similar to the tree based on homology of the core-genome since the evolution of both core and pan genomes would then follow the same molecular clock.
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These findings helped in understanding the intraspecies (strains) diversity and/or similarity and its correlation with that of phylogenomic variations based on genomic contents.
We calculated the usage of all the 61 codons (excluding the start and stop codons; of note, we excluded the first Met encoded by start codon in CDS, which would lead to biased analysis of amino acid usage) in all the 65 genomes that were first orderly ranked based on genomic GC-content.
As shown in Figure 1A and Supplementary Table S1, the features consisted of HAc (acetylated H4) ChIP-Seq data from activated and non-activated macrophages; VS derived from the HAc data; and three features based on genomic sequence (GC content, vertebrate species conservation and a nucleosome occupancy prediction score).
Table 2 indicates the factors influencing comparisons based on genomic signatures, with AT content being the strongest.
This was achieved by the use of quantitative TaqMan real-time polymerase chain reaction based on genomic DNA derived from pet food contents that were presented in a variety of physical states.
Today, if one wants to have access to a holistic approach to medicine based on genomic understanding, it means investing around $2,000 in one's own health.
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based on genomic correlation
based on genomic diversity
based on genomic expression
based on genomic understanding
based on genomic position
based on genomic variation
based on visual content
based on genomic sequence
based on genomic location
based on genomic organization
based on genomic testing
based on thematic content
based on genomic alteration
based on genomic information
based on genomic analysis
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