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The genetic mechanisms that underlie the individual variation have been investigated through approaches based on genome sequencing.
Based on genome sequencing, the two extant orangutan species evidently diverged around 400,000 years ago.
The 1000 Genomes Project is based on genome sequencing reads from 1092 individuals from locations worldwide [ 41].
Application of massively parallel methods identified one third of the complete proteome, a majority of which was only predicted based on genome sequencing, but never identified to date.
Molecular epidemiology, based on genome sequencing of the early isolates, also provided evidence that Beijing infections were closely related to those from the Guangdong epidemic (4 ).
First, a set of high confidence variants was called for each mutant with VarScan (Koboldt et al. 2012, 2009) based on genome sequencing data from the mapping strain and genomes of the segregant bulks, with reads from both bulks merged.
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In this regard, phylogenetic approaches based on genome sequences (e.g., sequence concatenation) and the genomic content of genes has been successfully used to build phylogenies at various taxonomic levels, including trees of organisms [ 4, 5].
Here we report the results of comparative analyses based on genome sequences of four newly isolated C. perfringens phages and focus on the genomic context and evolution of the phage endolysin genes.
Complementary approaches based on genome sequence information and subsequent annotation of biosynthetic pathways are emerging technologies.
Based on genome sequence of the strain Tohama I, all the four absent loci were flanked by IS481.
We propose using "genotype" rather than "serotype" as a means for identifying, characterizing and differentiating adenoviruses, based on genome sequence analyses.
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based on genome coverage
based on genome location
based on genome availability
based on genome analysis
based on genome arrangement
based on genome size
based on genome assembly
based on genome structure
based on genome engineering
based on genome position
based on genome annotation
based on genome segment
based on genome context
based on shotgun sequencing
based on deep sequencing
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