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Since the most important findings of this paper, the identification of the YoqW and ImuB-C domains, was based on genome context analyses, one is left wondering about the easy reproducibility of the finding, given that this is an in-house package.
In SEED large homology-based protein families are broken into isofunctional subfamilies ('functional roles') based on genome context, functional context, phyletic profiling, shared regulatory sites, and other homology-independent clues.
The strategy for constructing the phylogenetic tree based on genome context was a newly developed system in evolutionary research [23].
As alternatives to analytical tools relying on sequence similarity, there are tools based on genome context.
Members of these transporter families in sequenced genomes were identified by homology searches and the function of each protein was predicted based on genome context (see Methods).
The associations are derived from high-throughput experimental data, from the mining of databases and literature and from predictions based on genome context analysis.
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Based on genome contexts of various species, proteins pertaining to mitochondria have been identified.
This problem, namely the clustering of genomes based on genomic context, is becoming more important as the number of sequenced genomes increases rapidly.
Although a number of computational methods related to gene distribution and genome rearrangement exist, most of them are not capable of clustering whole genomes based on genomic-context information, hence the development of this work.
Recently a number of genome analysis methods have been developed that predict protein-protein interactions and functional associations between proteins based primarily on genome context and not directly relying on sequence homology [ 1- 6].
The gene context is based on genome sequences to infer in silico protein-protein interactions [ 22].
More suggestions(17)
based on genome science
based on such context
based on genome size
based on genome structure
based on genome engineering
based on genome position
based on genome annotation
based on local context
based on genomic context
based on genome coverage
based on genome location
based on genome sequencing
based on genome genome
based on genome analysis
based on genome arrangement
based on genome assembly
based on learner context
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