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Relationships among pathovars based on genome content similarities were also analyzed (fig. 4).
This points to the utility of constraint based models for making detailed functional predictions based on genome content, as well as the importance of correct genome annotation.
Based on genome content, it appears that all of the AMD plasmas have the capacity to grow both aerobically and anaerobically.
Pathways, reactions and compounds can also be easily accessed through the cellular overview, which displays a map of all pathways and reactions predicted to be carried out by the strain based on genome content and manually curated published data.
In this study, we made predictions of function based on genome content using genome sequences of six human-derived L. reuteri strains that represent clades II and VI (see fig. 2 and supplementary fig. S1, Supplementary Material online).
We did not find any support in a generation of ecotypes or an adaptation to the corresponding origin or host by distinct metabolic features based on genome content which were confirmed by BIOLOG analyses (Additional file 2: Table S6a/b).
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Comparative genome hybridization (CGH) studies have demonstrated small differences between F.t. tularensis and F.t. holarctica populations based on genome contents.
Without a reference genome, the total number of restriction sites can be simply predicted based on genome size and GC content by assuming sites that are Poisson distributed.
Estimates of gene content based on genome size are possible; recent work by Hou and Lin [ 47] shows a strong non-linear correlation between genome size and protein-coding gene number across a broad range of eukaryotes.
To estimate a phylogeny based on genome similarity in terms of gene content, a distance matrix was constructed where the distance measured between two taxa is inversely proportional to the number of genes shared between them (Snel et al. 1999; Kettler et al. 2007; Georgiades et al. 2011).
Indeed, based on genome variations in CpG and G+C content, it has been suggested previously that species-specific CpG island annotation may be required (Glass et al., 2007).
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based on genome science
based on genome location
based on genome genome
based on genome annotation
based on genome arrangement
based on genome position
based on genome structure
based on genome size
based on genome analysis
based on genome engineering
based on genome substraction
based on genome coverage
based on genome segment
based on genome sequence
based on genome sequencing
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