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Since the homology between murine and human genomes is over 75%% [ 22, 23], we hope to make inroads towards the targeted identification of high-risk patients based on genetic screening, and a personal medicine-based approach to treatment.
The biological relevance of the genes identified was supported by two independent sources, namely differential expression in the microarray experiment analyzed and known disease associations based on genetic screening or mechanistic studies.
These observations seem to offer the possibility of personalised medicine based on genetic screening for 'high-risk' individuals – i.e. a novel method for the safe use of centrally acting CB1 receptor antagonists.
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The workflow described here provides a general paradigm for recovery and characterization of microbially derived genes and gene products based on genetic logic and contemporary screening technologies developed for model organismal systems.
This is the first population-based study investigating women's attitudes to risk-stratified mammography screening based on genetic risk assessment.
The results of this study indicate that women are generally positive towards risk-stratified mammography screening based on genetic risk assessment; although it will be important to develop effective communication materials to minimise resistance to reduction in screening frequency for those at lower genetic risk.
Three poorly characterized ORFs suspected to play a role in ER function based on genetic interactions in high-throughput screens also were identified in our screens (Jonikas et al. 2009).
To explore public attitudes towards modifying frequency of mammography screening based on genetic risk.
Risk-stratified mammography screening based on genetic risk could therefore be superior to current age-stratified approaches [11,12].
Data were from a large, population-based study, making it possible to identify demographic and personal predictors of support for raising or lowering frequency of cancer screening based on genetic risk.
Given that research is under way to test the feasibility of 'personalising' mammography screening based on individual risk factors, including genetic risk [29], the primary aim of this study was to investigate public attitudes towards amending the frequency of breast cancer screening based on genetic risk in the current UK National Health Service Breast Cancer Screening Programme.
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CEO of Professional Science Editing for Scientists @ prosciediting.com