Sentence examples for based on genetic changes from inspiring English sources

Further analysis indicated that the clinical isolate had increased constitutive expression of mRNA transcripts when grown in vitro when compared to the mRNA expression in the sequenced PA01 strain, indicating that many of the phenotypes that had emerged during chronic infection were based on genetic changes that were not markedly affected by transfer to the in vitro state for bacterial growth.

It is unnecessary to update the vaccine based on genetic changes that do not affect the antigenic properties of the virus.

The main motivation for this review series was to confirm or refute evidence for phenotypic change as a result of (adaptive) evolution, based on genetic changes in wild populations.

In addition, it has recently been proposed that ovarian cancer can be divided into two groups based on genetic changes: low-grade (type I) and high-grade (type II) ovarian cancer [ 10, 11].

Although cancer cells generally obtain the ability to autonomously proliferate based on genetic changes in the key molecules involved in the regulation of cell growth, they are also supported by extrinsic signaling derived from growth factors and cell adhesion.

RAMI produces clusters of sequences based on genetic change (the so called patristic distance) instead of a score-based genetic distance, which should result in accurate and evolutionary robust clustering.

While present methods use universal thresholds to identify OTUs, RAMI recognize clearly resolved clusters of sequences based on genetic change in phylogenetic trees.

In our human tissues, on the other hand, the "normal" tissue was tumor-adjacent and several studies have reported that tumor-adjacent histopathologically "normal" tissue is far from normal based on genetic and epigenetic changes (Cho et al., 2010, Anticanc Res; Yan et al, 2006, Clin Canc Res).

At the same time, it is often difficult to distinguish changes based on genetic evolution from those due to phenotypic plasticity (Merilä 2012; Merilä and Hendry 2014).

Commonly, the sequences are grouped into operational taxonomic units based on genetic distance (sequence similarity) instead of genetic change (patristic distance).

In conclusion, the current prognostic models based on genetic abnormalities are nowadays subject to change as new cytogenetic and mutational findings are revealed, contributing to refine better and better these approaches.