Sentence examples for based on genetic alterations from inspiring English sources
Prior evidence was classified as 'medium' for genes reported previously as playing a role in prostate carcinogenesis or progression but currently lacking statistical support based on genetic alterations.
The fact that only a small number of smokers develop COPD may be based on genetic alterations of common proinflammatory cytokines such as CRP and IL-6.
Our regression model allowed the identification of patients at high risk for metastasis even in an organ-confined situation based on genetic alterations of the primary tumour.
A number of genetic alterations have been correlated with prognosis [ 1– 5]; however, the ability to prognosticate outcomes and tailor treatment based on genetic alterations is still limited.
The development of familial and sporadic breast cancer is based on genetic alterations of tumour-suppressor genes, for which loss of heterozygosity (LOH) is one mechanism of gene inactivation.
In contrast to our results, the MAPK signaling cascade is non-significant in the study of McLendon et al., which is based on genetic alterations including validated somatic nucleotide substitutions, homozygous deletions and focal amplifications.
This combined approach thereby provides greater insight into the similarities and differences of related cancers, and how these features can guide targeted intervention not only based on specific genetic alterations but also on all alterations that can contribute to an alteration of targeted genes and pathways.
These profiles are unique for individual neoplasms because they include random alterations of genes that are non-essential for carcinogenesis and accumulate over time based on genetic instability.
