Based on gene knockout studies, C/EBPα and C/EBPβ appear to not only to affect gluconeogenesis, but also hepatic lipogenesis as well.
At least 30 of the STPKs play important roles in development, based on gene knockout studies [ 12].
A role of some family members in defense against pathogen attack had been proposed based on gene regulation studies and transgenic approaches.
Furthermore, based on gene expression studies of lupus patients, we have reported that the BM may be more informative than peripheral blood (PB) in differentiating active from inactive lupus patients and in differentiating patients from control individuals [ 9].
Although the expression and functional activity of these metabolic enzymes has not been quantified relative to other organs, their presence at the BBB endothelium has been postulated based on gene expression studies.
Based on gene expression studies of Mecp2 knockout mice and biochemical evidence, it has been suggested that the essential function of Mecp2 in the brain might not be transcriptional [ 49].
c- and N-myc are also essential for normal hematopoietic stem cell (HSC) function based on gene knockout (KO) studies [18], [19].
We used SRM to investigate the expression stability of 18 proteins/genes commonly reported as internal reference standards based on gene expression profiling studies [ 50, 51] (Additional file 1: Tables S3 and S4).
Based on gene expression profiling studies, Lehmann et al. showed that this aggressive type of breast cancer can be divided into seven subtypes as basal- like 1, basal- like2, immunomodulatory, mesenchymal- like, mesenchymal stem- like, luminal androgen receptor and unstable.
Based on gene-knockout studies in mice, pregnancy-associated growth and differentiation of normal mammary epithelia require Stat5a but not Stat5b [ 4, 9].
