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Our clustering results do not provide evidence for a link between Pfmc-2TM and the pyst-b gene family as has been proposed previously based on gene structural features [ 18].
It is important to note that, other than pir, the large 2TM superfamily is currently united solely based on gene structural features and not sequence similarity; in fact, to date no PfMC-2TM sequence homologs have been identified in P. falciparum or any other species.
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Based on gene expression (Table 1), protein localization and structural and kinetic properties of rice Hbs and data from the analysis of other plant and non-plant Hbs it is likely that Hbs play a variety of roles in rice plants growing under normal and stressed conditions.
Statistical functional enrichments can then be performed based on structural aspects of these relationships, whereas in traditional statistical analyses, capturing enrichments based on gene relationships is difficult at best [ 3].
Expand the genes based on the gene-gene interaction.
The APPRIS focuses on selecting one principal isoform for each multiexon gene based on structural and evolutionary information between species (31).
Several methods for in silico prediction of selenoprotein genes have been developed over the past decade, based on the structural characteristics of selenoprotein genes.
By following computational algorithms, the functional SNPs out of a vast range of disease susceptible SNPs of ATM gene [ 26], BRCA1 gene, and BRAF gene [ 27] have successfully divided based on their structural and functional properties.
In recent years, more than 20 plant genomes have been sequenced, and ~37,000 RGA genes were predicted based on conserved structural motifs [ 61].
In this report, we provide a comprehensive characterization of the extended family of human hsp70 genes and their proteins based on genomic, structural, and evolutionary analyses.
JH has been reported to influence gene expression in protozoan termite gut symbionts[ 21] and to play a role in Ca2+ homeostasis,[ 22] in addition to exerting epigenetic control of gene expression.[ 23] Based on their structural resemblances, similar activities might be exist for phurealipids.
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