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These differ from the HCC modules, as they are constructed based on gene sets derived by hierarchical clustering.
Additionally, GSEA for the on-target signatures was conducted using Fisher's exact test based on gene sets defined by KEGG pathways as annotated by the Bioconductor package KEGG.db version 2.2.0.
It is expectable that, where conventional methods for finding signatures from gene expression data are failing in capturing part of the functional information of the modules, methods based on gene sets [34], [35] and specifically those that consider the structure of the network [36], [37] will produce sounder results.
Enrichment analysis was based on gene sets including EHMN, KEGG, NCI and GO from GSEA.
All bioinformatic functional analysis was based on gene sets from GO [ 36], KEGG [ 37] and mSigDB [ 38].
To our knowledge Caipirini is the only service that can search literature directly based on gene sets.
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Noteworthy that most of these approaches were based on gene set enrichment (GSEA) statistical techniques [13].
These data were imported into javaGSEA desktop application v 2.0 [17], [17] where they were analyzed using 1000 permutations based on gene set, and signal2noise for ranking.
S and Pr could be defined for stimuli based on gene set or protein phosphorylation activation.
Functional annotations of the cancer network motifs are based on gene set enrichment analysis by implementing DAVID.
A prediction algorithm based on gene set enrichment analysis (GSEA) [ 14] was also developed to rank compounds based on input signature genes obtained from tumor comparison.
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based on gene insertions/deletions
based on character sets
based on gene IDs
based on bootstrap sets
based on skill sets
based on gene predictions
based on bond sets
based on gene diversities
based on gene models
based on gene transcripts
based on gene studies
based on gene pairs
based on privacy sets
based on basis sets
based on cut sets
based on gene tests
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