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These data were imported into javaGSEA desktop application v 2.0 [17], [17] where they were analyzed using 1000 permutations based on gene set, and signal2noise for ranking.
S and Pr could be defined for stimuli based on gene set or protein phosphorylation activation.
Functional annotations of the cancer network motifs are based on gene set enrichment analysis by implementing DAVID.
MSEA is based on gene set enrichment analysis (GSEA) and is used to investigate the enrichment of predefined groups of functionally related metabolites rather than individual metabolites.
A prediction algorithm based on gene set enrichment analysis (GSEA) [ 14] was also developed to rank compounds based on input signature genes obtained from tumor comparison.
The most noticeable pathways are multiple MYC target gene sets downregulated at highly significant levels, confirming our observation based on gene set overlaps.
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These differ from the HCC modules, as they are constructed based on gene sets derived by hierarchical clustering.
Additionally, GSEA for the on-target signatures was conducted using Fisher's exact test based on gene sets defined by KEGG pathways as annotated by the Bioconductor package KEGG.db version 2.2.0.
It is expectable that, where conventional methods for finding signatures from gene expression data are failing in capturing part of the functional information of the modules, methods based on gene sets [34], [35] and specifically those that consider the structure of the network [36], [37] will produce sounder results.
Enrichment analysis was based on gene sets including EHMN, KEGG, NCI and GO from GSEA.
To our knowledge Caipirini is the only service that can search literature directly based on gene sets.
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based on validation set
based on feature set
based on probe set
based on precedent set
based on test set
based on gene model
based on gene symbol
based on gene sequence
based on gene duplication
based on gene knockout
based on gene structure
based on gene order
based on gene prediction
based on gene homology
based on gene expression
based on training set
based on gene annotation
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