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Many of them are based on gene duplication and divergence, in which a randomly selected node is duplicated to generate a new node having the same links as the original node, and some links are added or eliminated in a divergence process [ 19- 23].
All these ideas are based on gene duplication.
These models are generally based on gene duplication and divergence.
Despite the great level of interest in models for the evolution of complexity based on gene duplication, data demonstrating how gene duplication can be implicated in the origins of novel protein-protein interactions are not common.
The second model is based on gene duplication followed by rapid sequence divergence [ 11, 12].
In models of network evolution based on gene duplication [ 17- 19], a protein acquires new links through duplications of its neighbors (see, for example, the grey nodes in fig. 1(c)), at a rate proportional to its connectivity.
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However this prediction of models based on gene duplications is not supported by the data.
Previous work by others [ 17- 19] shows how structural features of the network can in principle be explained through mathematical models of network evolution based on gene duplications alone.
Both the retrograde and patchwork theories attempt to explain the evolution of metabolic networks based on gene and operon duplication linking distribution of genes on the chromosome which may be affected by rearrangements and consequently on the structure of the metabolic network [ 12].
The main sources for gaining miRNA genes in plants are based on miRNA gene duplication events and local inverted duplication events of short segments from protein-coding genes [ 10].
We constructed a phylogeny of eukaryotic kinase families and undertook efforts to link gene duplication events to functional diversification or conservation based on gene expression data.
More suggestions(16)
based on gene order
based on gene deletion
based on gene percentage
based on gene copy
based on gene protein
based on item duplication
based on gene essentiality
based on gene orientation
based on layer duplication
based on gene architecture
based on gene prediction
based on gene sequence
based on gene knockout
based on gene symbol
based on gene model
based on gene expression
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