Sentence examples for based on gene co-expression from inspiring English sources
Hypothesizing that the current regulatory network model may not be accurate enough to make quantitative predictions (see Discussion), I opted to use a different strategy, based on gene co-expression networks.
GC and MF designed variable selection method based on gene co-expression and built UniHi db.
Also available are the functional prediction tools based on gene co-expression, such as [email protected], Genevestigator, ATTED-II and KAGIANA.
This method has been explicitly, or at least implicitly, employed in various studies on metabolomics [ 38- 40], neurodynamics [ 41], and transcriptomes based on gene co-expression [ 42, 43].
In contrast, analyses based on gene co-expression algorithms perform well across data types [ 7] and inspire working hypotheses since their results resemble hierarchical signaling networks.
Furthermore, to overcome the limited number of genes in the gold standard, we used a second validation method based on gene co-expression testing the ability of pipelines to predict co-expression of genes associated to the same GO-term.
Figure 2 shows an example of an interaction network based on genes' co-expression properties.
The concepts of party hubs and date hubs are first proposed by Hen et al. based on gene co-expressions, using filtered yeast microarray data [ 10].
Over-represented Biological Functions in the aortic endothelium of each strain after HFD were identified based on weighted gene co-expression.
Based on our gene co-expression network analysis, we observed that the non-random distribution of essential genes at early developmental stages in Drosophila development leads to different developmental stages showing varying levels of essentiality.
The components of this matrix (connection strengths) were then used to calculate 'topological overlap' (TO), a robust and biologically meaningful measurement of gene similarity based on two genes' co-expression relationships with all other genes in the network.
