First, on the global scale, the scientific community has to ensure that the public health benefits that arise from innovation based on gain-of-function research are made available to everyone.
That is, based on gains in quality of life, the cost-per-QALY-gained ratio is lower than the cost-per-life-year-gained ratio.
Based on gains in quality of life, the cost-per-QALY-gained ratio is lower than the cost-per-life-year-gained ratio.> -wrap-foot> Costs are in 2013 Canadian dollars and are rounded QALY quality-adjusted life-year Using a US value set for EQ-5D™ health states results in a cost-utility ratio of Can$35,250 per QALY gained.
In fact, the market may see some modest gains at the opening of trading, based on gains in S&P futures ahead of the opening bell today.
In addition they inherit feature selection by their alignment of decision nodes based on Gain Ratio in combination with pruning of lower nodes.
These conclusions are based on gain- and loss-of functions approaches using H9c2 cardiomyocytes, where we characterize the phenotypes associated with hypertrophied signaling and incorporate the functions of Anxa6 in the hypertrophic process.
Based on gain- or loss-of-function data collected in animal disease models using genetics or pharmacological modulation of microRNAs (miRNAs), it is now well accepted that miRNAs are important players during disease.
The proposed FTC design is based on gain-scheduling control in the framework of structured H∞ synthesis.
In contrast to screening for the loss of lacZα function, fluorescent protein-based screening is based on a gain of fluorescence that can increase screening fidelity as the fluorescence property cannot be acquired spontaneously.
Functional screenings based on the gain-of-function approach proved extremely valuable in the identification of novel genes involved in key processes related to cancer onset and progression, such as neoplastic transformation, resistance to apoptosis, or escape from senescence [ 1- 3].
However, most previous in vivo studies on FGF21 were based on the gain-of-function approaches and whether endogenous FGF21 is an obligatory metabolic regulator remains unclear.
