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Innovative vascular therapies based on GAG mimetic should be developed.
Vaccine strategies based on Gag or possibly any HIV-1 protein as immunogen may not be effective in preventing natural infection because of the large number of HIV-1 genomic variants as potential altered epitope peptides.
Phylogenetic analyses performed based on gag are rarely reported, due to the fast rate of evolution of this polyprotein.
Therefore the chromoviral scenario does not explain why class I and Athila/Tat elements of plants are similar each other based on gag.
Neighbor-joining and maximum parsimony phylogenetic trees based on gag sequences confirmed that Athila is a complex ensemble, formed by highly differentiated families.
Based on GAG quantification and gene expression analysis, encapsulated passage 1 cells cultured in growth medium displayed the best ectopic chondrogenesis.
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GAG protein interactions can be based on: (1) GAG sulfation pattern; (2) GAG carbohydrate conformation; (3) GAG polyelectrolyte behavior.
Two subjects, A and PO, demonstrated distinct patterns for gag and env distance distribution, suggesting transmission of a single variant based on the gag distance distribution, but two viral variants were evident from the distribution of env distances.
Based on 24 gag cDNAs pooled from 4 mamma-CA specimens, 21 env cDNAs from one mamma-CA, and 22 gag cDNAs and 19 env cDNAs from normal breast tissue, we identified 7 and 11, respectively, transcriptionally active HML-2 proviruses.
However, matrix production was improved in chitosan fibrous constructs based on the GAG quantification and collagen II mRNA expression.
Four digit high resolution Characterisation of the infecting viral subtype was based on the Gag sequences as described below.
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