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Since this therapeutic strategy is based on functionalities that the tumor has lost (and which usually cannot be gained again through additional mutations), it can be expected to be more robust against the development of resistance mechanisms than other targeted therapies.
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When not fully functional replicators are viable (i.e. selection is based on functionality instead of replication), replicators can suffice with lower functionality under increased mutation rates.
An hypothesis that clarifies the presence and diversity of the Fur homologues in Actinobacteria is presented, leading to a stable protein family division based on functionality and phylogeny.
Subjects were classified on the basis of a dichotomized five level branching hierarchy of dental functional status in which the criteria applied on the levels are based on conditions that reflect functionality [ 20, 21] (Table 2).
In the classification system [ 19], dentitions were classified on the basis of a dichotomized five level branching hierarchy in which the criteria applied on the levels are based on conditions that reflect functionality (Table 2).
The functionality is estimated based on hospital losses that result from its sustained damage as well as damage to other lifelines on which the hospital relies.
Therefore, more than 80% of confidently negative reactions based on transcriptomic data that were retained for functionality considerations by mCADRE do in fact have some proteome-level evidence.
Recently, we developed a strategy based on RNA DNA hybrids that can be generally used for triggering activation of different functionalities in vitro and in vivo.
How It Works, the science-based flagship title in the publisher's portfolio of 20 magazines is based on that same thirst for understanding functionality.
Our hypothesis is based on the observation that Aβ decreases spontaneous activity of neurons at low concentrations and that this has a deleterious effect on cell functionality without significant cell death.
However, some functionality can be assigned to each of the four clades based on known functionalities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com