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It is possible that personal MLDMs could become a cornerstone for health care, and could be used for the early diagnosis of changes in module function, based on functional understanding of why disease-causing nodes in the MLDMs change (such as due to a genetic variant).
Ideally as many phenotypes, genes and other disease-associated variables as possible should be studied together in order to reclassify diseases based on functional understanding of underlying mechanisms.
Similar to the current diagnostic model discussed above, analyses can be based on functional understanding, but with higher resolution and the option for computational predictions.
MLDMs could also be used to stratify patients for individualized medicine based on functional understanding of why patients do or do not respond to a particular drug.
The clinical relevance of MLDMs lies in that they can provide a framework to identify optimal combinations of diagnostic markers from different layers, based on functional understanding of the pathogenic roles of those markers.
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In these areas, an understanding of the patch system based on functional correlations or fine resolution population anatomy might be necessary.
Health literacy assessment is frequently based on functional measures that determine basic reading skills, skills for discussing and understanding text, and being able to do numerical calculations [ 2].
Dynamic causal modeling (DCM) based on functional magnetic resonance imaging (FMRI) and magneto-/electroencephalographic (MEEG) data has increasingly extended the understanding of intrinsic brain network dynamics in a variety of functional systems (Friston et al., Curr Opin Neurobiol, 2013).
Community analyses based on functional traits that capture marine species' vulnerability to climate change and OA can improve our understanding and predictive ability of how the structure and function of marine ecosystems is affected under current and future climate change scenarios.
Significant progress has been made in our understanding of changes in T cell responses during immunotherapy, but existing work has largely been based on functional T cell assays.
The functional gene repertoires were based on functional assignments of the metagenomes using the FOAM9 database.
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based on functional class
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based on scientific understanding
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based on functional disability
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based on functional aggregation
based on functional impairment
based on functional annotation
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based on functional transformation
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