Sentence examples for based on functional pathways from inspiring English sources

For this analysis, genes were grouped based on functional pathways.

The biological implications of this work are further strengthened by the observation that chemical feature selection based on functional pathway activity leads to more predictive toxicity models (sensitivity 78.1%, specificity 87.1%).

The profile determines the mRNA levels of 80 genes that discriminate between three breast cancer subtypes based on functional molecular pathways: Luminal, HER2, and Basal. 1 A further stratification of the Luminal group into types A and B is important to identify the risk of metastasis and has been related to tumor grade and/or proliferation (Ki-67 fraction or mitosis).

Praneenararat et al. [ 30] present NaviClusterCS for interactive and multi-scale network navigation in the big data era while Hsu and Yang [ 31] have uncovered pathway cross-talks based on functional relations between pathways.

Genes were classified based on functional category and pathways using Gene Spring GX Software and Genotypic Biointerpreter-Biological AnalySoftware and Genotypic Biointerpreter-Biological

Genes were classified based on functional categories and pathways using the MapMan (http://mapman.gabipd.org/web/guest/ mapman) and A. thaliana Gene Ontology softwares (TAIR's GO annotations) [ 95].

Differentially regulated genes were clustered using hierarchical clustering based on Pearson's coefficient correlation algorithm to identify significant gene expression patterns genes were classified based on functional category and pathways using GeneSpringGX Software and Genotypic Biointerpreter -Biological Analysis Software.

ToppGene was used to detect enrichment within each gene list based on functional ontologies (GO Biological Process, pathways) and phenotype [ 30 ]. Results were filtered to provide the lowest 25 by false discovery rate adjusted p-value (FDR B&H).

Our goal was to extend our results beyond lists of genes and ontological classifications to discover new pathways based on functional interactions.

In order to reduce this number to a reasonable number of candidate genes, one strategy consists in selecting candidate genes based on functional knowledge (for ex. known biosynthetic pathways; transcriptomic data; annotation inferred from homologous genes in other species) and check if the candidates co-locate with QTLs [ 11, 18, 19].

Of the total 47 genes from both SNP and methylation PSFs, we identified 13 shared functional clusters based on functional categories, gene ontology (GO) and pathway information.