Molecular-linkage maps based on functional gene markers (molecular-function maps) are a prerequisite for a candidate-gene approach to identify genes responsible for quantitative traits at the molecular level.
Flow cytometry can also be used to separate T cells based on functional activation markers such as CD69 or CD107 that appear transiently on the cell surface after exposure to cognate antigen.
Previous studies have identified various genes which either directly contribute to virulence or act as virulence markers based on functional studies [12], [62], differential distribution between pathogenic and less or non-pathogenic strains [20], [63] or genome comparisons [19].
The clinical relevance of MLDMs lies in that they can provide a framework to identify optimal combinations of diagnostic markers from different layers, based on functional understanding of the pathogenic roles of those markers.
These will facilitate and guide a progression throughout the rehabilitative process based on functional criteria, as opposed to less sensitive, time-related markers of progression, thus ensuring an individualised approach to management.
Although clones for marker development were not chosen based on functional annotation, the sequence data utilized were known to be transcribed.
Research based on functional magnetic imaging (fMRI) scanning, suggests that the brains of psychopaths have different automatic responses.
Classifications are based on functional mobility.
The IPC oversaw classification based on functional disability.
For this analysis, genes were grouped based on functional pathways.
