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More effective anticancer therapeutic strategies, many of which are based on functional genomics.
Therefore, reverse genetic approaches based on functional genomics might be quite useful.
As the cost of sequencing continues to drop and related technologies develop, increasingly comprehensive studies based on functional genomics are becoming feasible.
In pigs as in many other species, the numerous in vivo and in vitro studies on host-pathogen interactions [ 26- 34] and immunity stimulation [ 35, 36], are now often based on functional genomics approaches such as transcriptomic approaches [ 37].
There are reports based on functional genomics studies of several organisms, which indicate that only 15 - 20% of the genes are essential to the organism under a given condition [ 12].
Interestingly, we found that the majority of genomic regions for both Miz-1 and Myc binding (all binding sites, not just cobound sites) are located at least 1 kb upstream of TSSs (Miz-1 is 51%, Myc is 63%), while the current model of Miz-1 binding, not based on functional genomics data, suggests that Miz-1 binding elements (INR) are predominantly localized in the core TSS region.
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Insights into these mechanisms based on functional and genomics studies may lead not only to the development of new therapeutic approaches to control and improve AS and related disorders but also to avoid radiographic progression.
MAGs identified based on functional class and comparative genomics.
All Salinispora protein sequences identified as candidate MAGs based on functional class and comparative genomics were subject to phylogenetic analysis to test for a shared evolutionary history with bacteria derived from hyper-osmotic environments.
Our approach to the reconstruction of sugar catabolic pathways in a selected group of genomes was based on functional gene annotation and prediction using two principal comparative genomics techniques: (i) homology-based methods and (ii) genome context analysis.
Comparative genomics also revealed different patterns of evolution based on functional categorization.
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based on functional approximations
based on functional principles
based on integrative genomics
based on environmental genomics
based on functional requirements
based on functional networks
based on functional pathways
based on metabolomic genomics
based on functional equations
based on computational genomics
based on functional markers
based on functional annotations
based on functional areas
based on functional groups
based on functional tests
based on functional nanomaterials
based on functional reviews
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