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Molecular-linkage maps based on functional gene markers (molecular-function maps) are a prerequisite for a candidate-gene approach to identify genes responsible for quantitative traits at the molecular level.
Based on functional gene analyses, we hypothesize that the Gamma- and Epsilonproteobacteria are capable of autotrophic growth by oxidizing reduced sulfur compounds, and that the Deltaproteobacteria are also involved in sulfur metabolism.
An important R package ArrayPro (http://lei.big.ac.cn/download/open_download_page) is also provided for processing of microarray data and construction of networks based on functional gene sets.
Unsupervised hierarchical cluster analysis defined four subtypes, termed proneural, neural, classical, and mesenchymal, based on functional gene annotation and prior convention (Phillips et al, 2006).
The scheme is based on functional gene annotations that were inferred in the course of regulon reconstructions in the RegPredict server (see Methods).
Our approach to the reconstruction of sugar catabolic pathways in a selected group of genomes was based on functional gene annotation and prediction using two principal comparative genomics techniques: (i) homology-based methods and (ii) genome context analysis.
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From those genes we selected ones that relates to skin aging, based on functional Gene-Ontology clustering.
Burke C, Steinberg P, Rusch D, Kjelleberg S, Thomas T. Bacterial community assembly based on functional genes rather than species.
This tool provides different types of annotations for each gene, including annotations based on functional categories, gene ontology (e.g. GOTERM, PANTHER), pathways (e.g. BIOCARTA, KEGG_PATHWAY), protein domains (e.g. INTERPRO) and protein interactions.
Of the total 47 genes from both SNP and methylation PSFs, we identified 13 shared functional clusters based on functional categories, gene ontology (GO) and pathway information.
Based on functional annotation, gene ontology (GO) classification and hierarchical clustering, a subset of the 253 differentially-expressed TCs (Table 1) was used to develop a model that could explain the higher AsA content in IL 12-4.
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based on functional connectivity
based on functional transformation
based on functional enrichment
based on functional conservation
based on functional unit
based on functional categorization
based on functional class
based on functional outcome
based on functional information
based on functional disability
based on functional mobility
based on functional approximation
based on functional aggregation
based on functional impairment
based on functional expansion
based on functional annotation
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