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These analyses are mainly based on functional association of changes in gene expression between different cell states or phenotypes.
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This review covers recent progress achieved in the wet-chemical development of HNCs based on functional associations of semiconductors, metals and magnetic compounds.
The list of 39 genes was then narrowed to five, based on functional annotation of the genes, association with clinical outcome in the Uppsala cohort, and correlation with tumor grade in an independent sample of 60 patients as described previously [ 5].
Although haplotype analysis has produced some interesting results, there remains the problem of nonreproducible results seen in genetic association studies based on functional SNPs.
Nevertheless, this study demonstrates that comparative proteomics is suitable to identify novel candidate genes and yields results complementary to association mapping based on functional and positional candidate genes.
Two general methods are available for studying candidate genes in gene association studies: approaches based on functional inference of individual SNPs within a gene of interest and methods that evaluate the association of the entire gene by using haplotype-based analyses.
To definitely show these associations are based on functional relationships, will require experimental work in the future.
The associations were identified based on functional link between miRNA targets and disease genes in PPI network.
In our study, we used a systematic approach to identify miRNA-disease associations, which was based on functional connections between miRNA targets and disease genes in PPI network, and a global network measure distance measure realized by RWR algorithm was utilized.
Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs.
Estimates based on functional mapping of the cerebellum using functional MRI suggest that more than half of the cerebellar cortex is interconnected with association zones of the cerebral cortex.
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