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Calculations of the follow-up rates over time were based on fixed effects in a mixed-effects Poisson regression model.
Prediction was based on fixed effects only.
Exploratory analyses based on fixed effects models were also conducted.
A microarray design based on fixed effects parameters which was applied here was originally described by Kerr and Churchill [ 34].
Where data have a hierarchical structure, researchers often face the choice between a model based on random effects and a model based on fixed effects.
Similar results were obtained for the incidence of fever or influenza-like symptoms (19.6% vs 36.3%), which was significantly lower for ibandronate based on fixed effects meta-analysis (RR 0.54, 95% CI 0.46 to 0.63, p<0.001; heterogeneity: I=80%) and slightly lower for ibandronate based on random-effects meta-analysis (p=0.05).
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Our results are based on fixed-effects estimates that allow for unobserved heterogeneity.
As it is acknowledged in the document, these recommendations are based on fixed-effects models.
The test for overall effect was identical whether based on fixed-effects or random-effects models (P = 0.03).
All combined trimester-specific ORs for term LBW in association with a 10-μg/m increase in PM10 were positive and comparable in magnitude based on fixed-effects models adjusted for maternal SES, with ORs of 1.01 (95% CI: 1.01, 1.01), 1.01 (95% CI: 1.01, 1.02), and 1.02 (95% CI: 1.01, 1.02) for the first, second, and third trimesters, respectively (Table 3).
Our simulated base ICER of $34,687 per QALY gained was somewhat higher than our simple 'expected value' base ICER of $27,572 because the simulated ICER is calculated from the average of 10,000 mean costs and mean effects based on several uncertain parameters with their assigned distributions while the simple ICER is based on fixed mean cost and effect estimates.
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