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Meta-analysis was conducted based on fixed effect model OR odds ratio, CI confidence interval, FDR false discovery rate.
The combined effects for the BCAC studies were also based on fixed effect models.
Here, we define eight different ways for pooling of cluster-specific estimates – both on the probability scale and on the log-odds scale – based on fixed effect meta-analysis and random effects meta-analysis.
Second, it is also possible that differences between pseudoword reading in Italian and English readers reflect false positives because the Z scores reported by Paulesu et al. (2000) were only significant at P < 0.01 uncorrected, did not survive a correction for multiple comparisons and were based on fixed effect rather than random effect analyses.
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Calculations of the follow-up rates over time were based on fixed effects in a mixed-effects Poisson regression model.
Prediction was based on fixed effects only.
Exploratory analyses based on fixed effects models were also conducted.
A microarray design based on fixed effects parameters which was applied here was originally described by Kerr and Churchill [ 34].
Where data have a hierarchical structure, researchers often face the choice between a model based on random effects and a model based on fixed effects.
Incidence of renal toxicity was lower in the ibandronate group (23.7%) than the zoledronate group (31.8%) based on fixed effects meta-analysis (RR 0.74, 95% CI 0.63 to 0.88, p=0.006; I=9%), although random-effects meta-analysis indicated no significant difference (p=0.18).
At this point, the OR based on fixed effects models suggested no effect whereas the OR based on the random effects model suggested a statistically significant benefit (which is expected to occur whenever a very large trial shows no effect and smaller trials show an effect).
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