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The corresponding results for anaemia-related symptoms (FACT-An) were similar to the FACT-F results, but were based on fewer trials; and tests for interaction failed to reach conventional levels of statistical significance, see Table 3.
The assessment of β blockers as inferior drugs for lowering blood pressure 14151617187 18 was based on fewer trials than were considered here; they had a similar protective effect on CHD to other drugs (fig 3) and a greater protective effect after myocardial infarction (fig 1), supporting guidelines that do not discourage their use.
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We performed several indirect comparisons to complement direct randomized comparisons, which were usually based on few trials.
Pooling information from trials that have carried out sub-group analysis based on similar baseline factors is reasonable, and may be useful even when based on few trials.
These recommendations are based on few trials directly comparing antidepressant drugs with different kinds of psychological interventions in primary care [ 21- 28].
However, a systematic review based on few trials concluded that cup feeding would not be so beneficial for preterm infants because it delayed hospital discharge and was associated with staff and parental dissatisfaction, even though it increased the likelihood of exclusive breastfeeding at discharge [ 16].
Most indirect comparisons (30 reviews) were based on fewer than 15 trials.
The majority of reviews (n = 14) were based on fewer than 10 trials: six of these had aggregated samples of more than 150 participants [ 108- 111, 119, 130].
14 The IRIS model was based on fewer assumptions about women's trajectories into and out of abuse and we used trial data instead of pilot data.
Nevertheless, given its low toxicity and based on few large, randomized prospective trials, NAC is currently included in prophylactic regimens in high-risk patients with impaired renal function [ 37– 37].
Estimates based on few patients are simply more uncertain.
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