Positive associations for all cardiovascular (0.88% (95% CI 0.63% to 1.13%)) and all respiratory (1.09% (95% CI 0.75% to 1.42%)) mortality were also observed, and though based on fewer estimates, we found positive summary estimates for mortality from other causes, that is, cardiac disease, ischaemic heart disease, stroke and chronic obstructive pulmonary disease (COPD) including asthma (figure 1).
Estimates based on few patients are simply more uncertain.
Third, Rogalsky et al. suggested that 53 65% of wood-burning homes in high-poverty communities may exceed health-based standards, but this estimate is based on few studies, with poverty assessed only at the community level.
The brain volume of some rare species was estimated based on few specimens (i.e., <3), which may affect the accuracy of the measures.
Sample size was estimated based on few previous similar studies, since data analyzing the association between viral co-detection and our main outcomes was scarce at the time this project was planned [ 16- 18].
The regression does not indicate changed mortality, though the estimates are based on few observations.
However, these estimates were based on few cases and results should be interpreted cautiously.
42 The Danish study also reported increased risk estimates for congenital abnormalities among newborns of women who were diagnosed with Hodgkin's disease during or shortly after pregnancy, but these estimates were based on few outcomes and were therefore imprecise.
Childhood leukemia was also associated with prenatal maternal occupational exposure to the broad pesticide classes of insecticides (summary OR = 2.72; 95% CI, 1.47 5.04) and herbicides (summary OR = 3.62; 95% CI, 1.28 10.3), but these estimates are based on few studies (Table 4).
It has been proposed that a minimal clinically important difference for exercise endurance time is in the range 46 105 s [ 23, 24]; however, these estimates are based on few studies and do not take into account the large variation in, for example, interventions, study methodology/duration, patient characteristics and disease severity, and exercise testing protocols.
