In this paper, the fast acquisition method based on fast Fourier transformation (FFT) is adopted.
Secondary end points included changes in body weight, fasting plasma glucose (FPG), 7-point plasma glucose profiles (before each meal, 90 min after breakfast, lunch, and dinner, and at bedtime), and β-cell function based on fasting insulin, fasting C-peptide, fasting proinsulin-to-insulin ratio, and the homeostasis model assessment index of β-cell function (HOMA-B) (15).
Secondary end points included changes in body weight; FPG; seven-point plasma glucose profiles; β-cell function based on fasting insulin, fasting C-peptide, and fasting proinsulin-to-insulin ratio; the homeostasis model assessment (HOMA) for β-cell function (HOMA-B) and insulin resistance (HOMA-IR) (13); and lipids.
Diagnosis of diabetes was based on fasting glucose test only.
However, IRS was defined based on fasting insulin.
Titration will be based on fasting blood glucose level (as given in Figure 1).
The ESC guidelines specify treatment targets based on fasting triglyceride levels.
Based on the same parameters, i.e., the ratio fasting proinsulin divided by fasting insulin and the ratio AUC proinsulin divided by AUC insulin, we could not detect any reliable association of the MTNR1B tagging SNPs with proinsulin conversion (all p≥0.04).
Sitagliptin also improved FPG, HOMA-B, and fasting proinsulin:insulin ratio but had a neutral effect on body weight.
