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A 2012 update of the Beers criteria categorizes selective serotonin reuptake inhibitors (SSRIs) as potentially inappropriate medications in all older adults based on fall risk.
Therefore, changes in the current treatment guidelines or policies on the use of SSRIs in older adults based on fall risk may not be justified at this time given the lack of an established evidence base.
7 54 To explore possible reasons for heterogeneity, we carried out pre-planned subgroup analyses based on fall risk at enrolment and found no difference in pooled estimates between trials with participants selected for their higher risk of falling versus lower risk (unselected), for any of the four categories of injurious falls.
18 We conducted a prespecified subgroup analysis based on fall risk at enrolment (a priori); that is, trials with participants selected for inclusion based on fall history or other specific risk factors for falling (at higher risk) compared with non-selected participants.
Among the women examined and eligible for the trial, risk of falls (based on history of falls, fear of falling, physical performances, and perceived physical health) did not differ significantly between those who accepted and those who refused to participate, which indicates that no additional self selection (based on fall risk) occurred above and beyond our intended selection process.
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Randomised trials have shown that multifactorial interventions, either based on falls risk assessments, or a range of general interventions introduced for all residents can reduce falls in residential care settings [ 6- 8].
Risedronate has been shown to be effective in women up to the age of 80 but was not effective in older women who were assigned to treatment based on falls risk but not because of osteoporosis (McClung et al 2001).
Participants included in this study were referred by health care providers to the study based on perceived fall risk and specifically sustaining a fall in the past 12 months.
We assessed RCTs that compared multiple component interventions, where participants received a fixed combination of two or more interventions that were not individually tailored based on a fall risk assessment, with a control.
The NP provided a weekly class with evidence-based education on fall risk factors.
All of these gloomy projections of falling stock prices have been based on falling valuations, not falling earnings.
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