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MCF10A is particularly useful for the present studies as based on expression profiling studies it expresses markers most often associated with the basal-epithelial phenotype.
Although cancer stem cell populations have been identified in these tumors [ 41- 43], one cannot conclude that these bear resemblance to MaSCs based on expression profiling studies.
Almost invariably these approaches were based on expression profiling, which in tumor samples is probably correlates and late events, among the steps leading to tumor development and progression.
Distinguishing direct versus indirect effects based on expression profiling, however, is difficult since MYCN regulates other transcription factors as well as regulatory RNAs such as miRNAs.
In addition, filtering based on expression profiling allowed the constrution of 65 cell-type-specific models.
Three other ABF/AREB transcription factors are predicted to function in ABA-dependent stress signalling based on expression profiling and overexpression studies.
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In which, the gene/protein network can be the protein interaction network as in [32], the gene semantic similarity network as in [34] as well as one constructed based on expression profiles of genes.
Both unsupervised, hierarchical cluster analysis and supervised, 2-cluster K-means analysis (data not shown) revealed complete separation of the autistic and control groups based on expression profiles of the differentially expressed miRNAs.
We defined an embryonic mammary signature based on expression profiles of genes found highly expressed within midgestation (E12.5-stage) embryonic epithelium compared with postnatal mammary epithelial cells described in Additional file 2[ 13, 13].
Co-expressed gene clusters were predicted based on expression profiles and genomic locations.
Genes encoding non-transcription factor (NTF) proteins (2,456) were further classified based on expression profiles to establish the composition of various co-expressed groups (regulatory clusters) controlled by the different classes of TFs listed in Table 1.
More suggestions(17)
based on expression evidence
based on expression spontaneity
based on distortion profiling
based on miRNA profiling
based on metabolite profiling
based on expression similarity
based on expression level
based on mRNA profiling
based on expression enrichment
based on gene profiling
based on protein profiling
based on laser profiling
based on expression perturbation
based on microarray profiling
based on expression style
based on expression randomisation
based on transcriptome profiling
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