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Examples of statistical tests to identify differentially expressed genes based on expression indices include the t-test, the non-parametric Wilcoxon rank sum test, Bayesian methods [ 4- 6] and permutation based methods [ 7].
Tests based on expression indices were carried out on the RMA probe set summary values.
Cyber-T is a regularized t-test based on expression indices [ 6].
Tests based on expression indices (Cyber-T, moderated t and ordinary t) were carried out on the log2 transformed expression indices.
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In this study, a novel method is proposed to predict the dynamic distribution of contaminants over a long time period in a complex recirculating ventilation system, where an algebraic expression based on the indices of the response coefficient is applied to account for the relationship between the contaminant distribution inside the room and various boundary conditions.
Seven GAPDH isogenes, 13 actin isogenes, 31 ubiquitin isogenes, and 23 cyclophilin isogenes were evaluated based on an expression stability index calculated with the scheme presented in Fig. 1.
Kaplan-Meier curves for PFI and OS, based on BEC-index mRNA expression, are shown in Figure 2C and D. The median PFI was significantly longer in the group with high compared to the group with low BEC-index (9.8 and 5.3 months, respectively, p = 0.028).
Recently, Sortiriou and colleagues have developed the gene expression grade index (GGI) based on the expression of 97 genes related to proliferation.
The invasive tumour was classified as pT1aN0Mx with a proliferative index based on Ki67 expression of 35%.
Furthermore, these data demonstrate that although the model was based on gene expression data and instability index data from mice that differed in age and genetic background, it nevertheless has significant predictive power.
Several quantitative methods based on these indices have been developed.
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