Sentence examples for based on expression changes from inspiring English sources
Based on expression changes between clusters, the function and regulation of genes can be predicted.
Essentially, the transcriptional inference is based on expression changes of the target genes of a TF.
Given gene expression profiles for tumor samples, we use the BASE method [ 20, 21] to infer TF activities based on expression changes of their target genes.
The present paper is based on expression changes in a gene subset derived from a genome-wide microarray analysis of biopsies of 52 breast cancers including the focus subgroup of 15 tumours, clinically resistant to neoadjuvant treatment with letrozole.
Lastly, a ranked sum analysis that ranked genes based on expression changes correlated with the levels of miR-203 showed that genes with the 8-mer or 7-mer seed ranked significantly higher than those transcripts without seed matches.
In the criterion to choose candidate lncRNAs based on expression change, we first selected the lncRNAs whose expression was changed more than two fold in any Pi-treated sample compared to that in untreated samples.
In the latter 2 data sets, we classified genes only based on expression change (positive vs. negative, and > 2 fold change vs. < 2 fold change), and used these classes for estimating the FDR (Additional files 8, 9).
The core set of regulated genes was divided into two groups for each dataset based on expression change; genes altered at least two-fold and genes altered less than two-fold under that specific germination condition.
The data were filtered based on expression level changes of greater than 1.5-fold.
The analysis was based on expression fold changes between miR-143 and mock transfection of all genes on the array without any cutoffs, and p-value less than 0.01 was used for statistical significance.
More problematic is the possibility that, as candidates are identified based on expression profile changes after inhibition of NMD, many indirect NMD targets are included [ 31, 39] (for example, those up-regulated by a protein made from an NMD-regulated gene).
