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Thus by two different approaches, one based on expression, and the second solely on binding site association, PPARγ primarily regulates a transcriptional cassette that is involved in lipid and fatty acid metabolism.
h,i, Cluster reliability (h) and silhouette score (i) for each sample from the four-cluster structure based on expression and the five-cluster structure based on VIPER-inferred protein activity data.
Hence, we selected the SMYD3 candidate gene based on expression and possible biological relevance to cancer.
Using this strategy 13 candidate genes based on expression and function data (see Additional file 6: Table S7) were identified.
Based on expression and functional analyses, we conclude that both Pericardin and Laminin A function in maintaining adhesive interaction with the hemocytes aiding in formation of the clusters.
Additional files 7 and 8 report the module membership (based on expression and methylation profiles) of all genes in all modules.
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The tool provides the functionality to parse KEGG KGML files and edit interactions based on expression data and external protein-protein interaction networks.
Co-expressed gene clusters were predicted based on expression profiles and genomic locations.
The avian β-keratins were originally grouped into four subfamilies (claw, feather, feather-like, and scale β-keratins) based on expression profiles and sequence heterogeneity [ 29- 31].
The differentially expressed genes identified were organized into clusters based on expression patterns and predicted function.
The two C-clade genes GAGA1 and GAGA2 have been considered similar in their function based on expression patterns and transgenic analysis.
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