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Inputting all qPCR data resulted in the classification of treatment groups based on exposure doses.
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Our observations are based on exposure to lower doses that were limited to the embryonic period.
The scientific committee acknowledged that the evidence of health risks was based on exposure to very high doses of hormones.
Six studies provided effect estimates based on cumulative exposure (dose).
As will be seen in the following section, the evidence for in vivo genotoxicity is relatively weak, and most of the positive findings are based on nonphysiological doses and exposure routes, and may be the result of oxidative mechanisms.
These results are noteworthy in that they are based on low-dose exposures, following the rationale that subtler effects that may not be morphologically apparent are likely to be discernible through behavioral changes.
The U.S. EPA derived reference doses (RfDs) for acute and chronic exposure to 2,4-D are based on external exposure metrics (administered dose), which are not directly useful for evaluating biomonitoring data.
Size-specific dose estimate (SSDE), a dose estimate based on BW, CT dose index, dose-length product, and effective dose were analyzed.
On the cytogenetic level, each irradiation type had special interference with DNA of PMC and exhibited wide range of mutagenic action on the frequency and type of chromosomal anomalies, fertility of PGs and seed yield productivity based on the irradiation exposure dose and radiation sensitivity of faba bean plants compared with un-irradiated ones.
In chronic oral toxicity studies in animals with MK-0941, cataracts were observed in rats and dogs at drug exposures of 3 and 1.5 times, respectively, the maximum predicted human exposure based on doses planned for further clinical development.
*Prenatal exposure based on final exposure designation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com