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In the current studies, the approximate 80 mg/kg/day dose used was based on experience where such a dose by a majority of ARIs either prevented or significantly delayed diabetic cataract formation as illustrated by the laboratories of Kador [28], [29], [58] and Kinoshita [59], [60], [61].
The productivity figures quoted above are based on experience where suitable sized stones were available in-field (productivity 0.5 m3 person-day) or in the immediate locality (productivity 0.33 m3 person-day)^ These rates of productivity would decrease significantly if stone has to be transported over greater distances and/or is of too large a size and has to be broken.
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Instead of relying on the learning goals that can be perceived as a paper product, the learning outcome is based on experiences where the apprentices learn from everyday activities in the workplace.
We chose the conditions of our screen based on experience with S. Typhimurium where motility agar at 37°C is a good condition for observing sdiA-dependent activation of chromosomal fusions.
Based on experience from previous studies where difficulties in obtaining contact information and data from some groups of professionals were encountered [ 21], it was decided to focus on a limited number of groups.
This approach is largely based on experience with ESRD patients where dialysis is only initiated when the glomerular filtration rate (GFR) has declined to <5-10 ml/minute and the patient is symptomatic.
Based on experience to date, even where the same logic applies as when a medicine is viewed by NICE as not being adequately cost-effective at the price the company has chosen, the company is rarely (if ever) seen as the villain of the piece 'demanding' too high a price; rather, the NHS is viewed as failing to find the necessary money for a new drug.
MS data were acquired under -ESI based on experience and a recent paper, where 93% of the tested 719 microbial natural product and mycotoxin reference standards were detected using -ESI positive mode.
They corresponded to very small tumors in two cases and to completely calcified meningiomas in two other cases where, as expected based on experience in human pathology, no contrast enhancement was seen on T1-weighted sequences.
Based on experience from the diabetes biobank at Vejle where patient samples were handled and stored at 5°C, it was initially proposed to handle and transport samples at 5°C, but most general practitioners do not have the equipment for handling blood samples at low temperature.
The number chosen (60 men+60 women/10 year stratum) was based on experience from clinical studies using the KOOS where a clinically significant difference often is set to 10 points and standard deviations in the magnitude of 10-15-20 have been seen in different populations and at different time points following interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com