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Predictions could be based on existing risk scores, if available, or a newly developed model.
Because the three prediction methods resulted in similar net benefit, treatment prediction based on existing risk scores is most appropriate in clinical practice.
Methods Data from the Justification for the Use of Statins in Prevention trial were used to predict rosuvastatin treatment effect for individual patients based on existing risk scores (Framingham and Reynolds) and on a newly developed prediction model.
26 Predictions of treatment effect should therefore be based on existing risk scores developed in external data when possible. 2 7 Yet even when validated risk scores are available, as in our example, developing a new prediction model fit to the trial data can help to confirm the assumption that treatment effect increases linearly with baseline risk (fig 1).
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Almost half of the studies have modelled the intervention effectiveness based on existing risk-factor information and effectiveness evidence from high-income countries.
The reasons for this finding are uncertain, but this lack of correlation reduces the potential impact of screening strategies based on existing clinical risk stratification.
The cost difference between a biologically targeted and a national coverage approach is substantial, at least 55 million United States dollars (US$) for commodities alone, assuming the current price of about 5 US$ per LLIN, highlighting the benefits of a more effective spatial targeting of intervention delivery based on existing coverage, malaria risk and population settlement.
Can we exploit the Bayes-minimax duality to derive new risk-limiting audits based on existing Bayesian ones?
Rangel et al. (2015) propose a comprehensive SC risk classification based on existing conceptual frameworks to further the consensus between different risk classifications.
But it could immediately begin to assess counterparty risk based on existing data.
Multivariable conditional logistic regression models were constructed, including a priori chosen covariates, primarily based on existing evidence on liver cancer risk factors.
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