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(A) Tree based on existing genes in GenBank.
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Simulation approaches for computing power and sample size that are based on existing gene expression data provide a powerful tool for efficient design of follow-up genomic studies.
Cliques of predicted 1-to-1 orthologs were identified and an annotation enrichment model was defined based on existing gene-GO term associations and phylogenetic relationships among wheat and 9 other plant species.
Since avian gene nomenclature is to be based on existing human gene nomenclature where possible [ 8], the first step is to identify strict 1 1 chicken:human orthologs and assign these chicken genes symbols and names based upon the human nomenclature.
Based on existing findings, dopaminergic genes DRD2 and SLC6A3 are believed to be candidate genes for dyslexia.
Because they are designed based on existing genome annotations, gene expression microarrays cannot facilitate the discovery of unannotated genes.
In silico computer analysis is based on existing information about gene functions and interactions and provides little information about genes that are differentially regulated but poorly annotated.
Two major mechanisms allow for creation of new genes based on existing templates: duplication of chromosomal regions containing gene loci and retrotransposition of mRNA transcripts into the genome - a process which in mammals is facilitated by active LINE-1 retrotransposons (L1s) [ 2, 3].
Because of the limited number of genes annotated under the ontological term "Megakaryocyte differentiation", we curated a list of 57 Mk genes based on existing literature [ 4, 24- 31] that are represented on the Agilent Human 1A v2) array by a total of 64 probes (see Additional File 3).
Table 1 Prioritized IBS-risk genes based on existing published statistical evidence Gene Chr location Gene name Gene function Gene region Phenotype Key reference TNFSF15 9q32 Tumor necrosis factor (ligand) superfamily, member 15 Codes for TNF-like ligand 1A (TL1A), which contributes to the modulation of inflammatory responses.
BJ improved the annotation of Ostreococcus genes, based on existing annotations and databases search.
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